MedGene Summary

The accelerated pace of biological research and the advent of genomics have resulted in the prodigious accumulation of data about genes and their relationship to disease.  This information is scattered among millions of different records in sources such as Medline and OMIM.  In order to rapidly and comprehensively summarize the biomedical literature, MedGene used an automated approach to assemble disease-gene co-citation matrices from the titles, abstracts and MESH terms of over 11 million Medline records and normalized these gene-disease relationships into rank order.  The estimated false negative rate for this tool is 9.2%, whereas the false positive rate ranged from 22% to 30% depending on the strength of the association.  The resulting database can generate lists of genes for use in high-throughput screening experiments, can create disease-specific micro-arrays, and can sort the results of gene profiling data. 

Users can review:

1. A list of human genes associated with a particular human disease in ranking order
2. A list of human genes associated with multiple human diseases in ranking order
3. A list of human diseases associated with a particular human gene in ranking order
4. A list of human genes associated with a particular human gene in ranking order
5. The sorted gene list from other disease related high-throughput experiments, such as micro-array
6. The sorted gene list from other gene related high-throughput experiments, such as micro-array

On entry to the gene section, a menu is given for searching via gene name, symbol or locus ID. Genes are displayed ranked by a statistical term (of which there are several to choose). On displaying the results, a link is created to Pubmed, and entry to this then returns all of the citations relating to a particular gene and gene/disease in one search.

Return to Table 1.

  Related websites: Main HuGENet site | Greece Coordinating Centre | Canada Coordinating Centre